About the course

This course introduces you to the field of vascular cognitive impairment research. It is presented by VAST's original Program Manager, Jolene Phelps. Jolene has a PhD in Biomedical Engineering, during which she studied stem cell derived extracellular vesicles and their use as therapeutics in a number of different disease models, including their potential to induce angiogenesis (i.e., vessel formation) in cerebrovascular endothelial cells. A number of review papers are listed in additional resources which provide a good overview of VCI terminology, pathology, and diagnosis; as well as information on the neurovascular unit.

Curriculum

2 Chapters · 19 Lessons

  1. 1

    Introduction to Research in Vascular Cognitive Impairment

    1. (Included in full purchase)

      Introduction

    2. (Included in full purchase)

      Part 1: VCI Definition, Risk Factors, and Basic Pathophysiological Mechanisms

    3. (Included in full purchase)

      Part 2: Defining the Neurovascular Unit

    4. (Included in full purchase)

      Part 3: Methods of Diagnosis and Assessment for VCI

    5. (Included in full purchase)

      Part 4: Research Targets, Clinical Trials and Open Data Sets for VCI

    6. (Included in full purchase)

      Test Your Knowledge of VCI

    7. (Included in full purchase)

      Further Navigation of VAST Courses

  2. 2

    Additional Resources and Lectures

    1. (Included in full purchase)

      Additional Resources

    2. (Included in full purchase)

      Review paper: van der Flier, W.M., et al. Vascular Cognitive Impairment.

    3. (Included in full purchase)

      Review paper: Dichgans, M. & Leys, D. Vascular Cognitive Impairment.

    4. (Included in full purchase)

      Review paper: Smith, E.E. Vascular Cognitive Impairment.

    5. (Included in full purchase)

      Review paper: Inoue, Y. et al. Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

    6. (Included in full purchase)

      Review paper: Iadecola, C. The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.

    7. (Included in full purchase)

      Review paper: Schaeffer, S. & Iadecola, C. Revisiting the Neurovascular Unit.

    8. (Included in full purchase)

      Review paper: Biesbroek, J.M. & Biessels, G.J. Diagnosing Vascular Cognitive Impairment: Current Challenges and Future Perspectives.

    9. (Included in full purchase)

      Recorded Lecture from Dr. Katherine J. Bangen - The Role of Vascular Health in MCI and Dementia

    10. (Included in full purchase)

      Lecture on Small Vessel Disease: A Clinical Perspective (Dr. Eric Smith)

    11. (Included in full purchase)

      Lecture on Non-Alzheimer Dementias and Dementias with Mixed Pathologies (Dr. Eric Smith)

    12. (Included in full purchase)

      Recorded lecture from Katherine J. Bangen, PhD - The Role of Vascular Health in MCI and Dementia

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